Vitamin C linked to fewer deaths in blood disorder trial
Vitamin C may do more than support the immune system. In a phase 2 trial of people with precancerous or low risk blood cancers, daily vitamin C did not slow abnormal cell growth, but it was linked to favorable changes…
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Scientists say house cats could help unlock better cancer treatments for humans
Scientists have mapped the genetics of cat cancer on an unprecedented scale and found surprising similarities with tumors in humans. The findings could help bring precision cancer treatments to cats while also revealing new clues about how human cancers develop…
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A major risk of breast cancer screening may have been overestimated for decades
A new analysis suggests mammograms may lead to far less breast cancer overdiagnosis than some earlier studies indicated. Researchers reexamined all eight major randomized screening trials and accounted for differences in follow-up time, screening frequency, and screening after trials ended.…
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CRISPR could help doctors attack blood cancer without destroying healthy cells
Researchers used CRISPR to remove CD33 from donor stem cells, potentially giving doctors a way to attack aggressive blood cancers without destroying the healthy cells patients need after a transplant. In a 30-patient trial, the edited cells successfully took hold…
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This new drug could break cancer’s resistance to treatment
A new experimental drug called CS18 may help break through cancer drug resistance by disabling several of the defenses tumors use to survive treatment. It strengthened existing therapies, restored drug sensitivity in resistant lung cancer cells, and slowed tumor growth…
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NCI and CRUK Take on Cancer’s Toughest Problems
Cancer Grand Challenges brings together international, interdisciplinary teams to tackle problems no single scientist, institution, or country can solve alone. Learn how the NCI and Cancer Research UK partnership is advancing cancer biology, prevention, and treatment while training future leaders.
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Millions take calcium and vitamin D for bone health. A major review finds little benefit
A sweeping review of more than 153,000 adults found that calcium and vitamin D supplements, alone or together, do little to prevent fractures or falls in most older people. Researchers say the findings challenge routine supplementation for prevention and point…
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A deadly ebola relative is surging after years in the shadows
A growing Bundibugyo virus outbreak is showing how a little-known relative of Ebola can become a major threat when diagnosis and treatment options are limited. Experts warn that preparing only for familiar pathogens could leave the world vulnerable when rare…
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Scientists discover cells that cheat death and rebuild damaged tissue
Scientists discovered a population of cells that can start the process of programmed cell death, survive it, and then help rapidly rebuild damaged tissue. Their descendants become far more resistant to future damage, revealing a mechanism that could improve healing…
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New mesothelioma drug turns cancer’s own defenses against it
Scientists are testing a counterintuitive way to fight mesothelioma, an aggressive asbestos-linked cancer with few effective treatments. A new experimental mesothelioma drug kills cancer cells by disabling PRX3, an antioxidant defense that tumors use to survive intense oxidative stress. In…
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Cancer is rising in younger adults. Faster biological aging may help explain why
Cancer rates are rising in adults under 55, and new research suggests accelerated biological aging may be one piece of the puzzle. Scientists found that people from more recent generations tended to have bodies that appeared biologically older than those…
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Scientists discover strange link between low vitamin D and pain
Low vitamin D levels may make recovery from breast cancer surgery more painful, according to a study of 184 women undergoing mastectomy. Patients with vitamin D deficiency were three times more likely to experience moderate to severe pain during the…
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Advancing Childhood Cancer Research: A Conversation with Dr. Brigitte Widemann
In recognition of Childhood Cancer Awareness Month, NCI's Dr. Brigitte Widemann discusses recent advances in treatment, shared data, artificial intelligence, research participation, and survivorship. She explains why sustained federal investment and partnerships with patients, families, advocates, and researchers are essential…
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Scientists find a way to break pancreatic cancer’s protective shield
Researchers found that blocking IL1RAP could disrupt a powerful inflammatory network that helps pancreatic cancer survive treatment. In preclinical experiments, the approach reduced tumor-protecting cells and fibrosis while boosting the activity of cancer-fighting T cells. That could make chemotherapy and…
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UCLA scientists turn cord blood into powerful cancer-fighting T cells
UCLA researchers developed ready-made cancer-fighting T cells from cord blood stem cells that can attack solid tumors through two separate detection systems. In mice, a single dose controlled cancer and extended survival while avoiding a dangerous complication associated with donor-derived…
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DNA treatment cuts bad cholesterol by nearly 50% without statins
Researchers have designed a new DNA-based treatment that targets PCSK9, a protein closely tied to high LDL cholesterol and atherosclerosis. Their most effective molecule reduced PCSK9 protein by 87% in human liver cells and lowered cholesterol by 47% in genetically…
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Scientists find a bone-building switch that could fight osteoporosis
An experimental compound called AP503 significantly strengthened bones in mice by activating GPR133, a receptor that boosts bone formation while slowing bone loss. Because the same treatment has also been linked to stronger muscles, researchers see intriguing potential for combating…
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Ozempic and Wegovy linked to nearly 40% fewer asthma attacks
Semaglutide, the drug found in Ozempic and Wegovy, was linked to nearly 40% fewer asthma attacks in a large real-world study. It was also associated with about 20% fewer COPD flare-ups. Researchers say GLP-1 drugs may offer respiratory benefits in…
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Scientists find a new weakness in treatment-resistant prostate cancer
Researchers have found a potential way to attack prostate cancers that evade treatment by changing their cellular identity. Combining two types of drugs reversed many of these changes and sharply slowed tumor growth in preclinical experiments, offering a possible new…
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Early statin use linked to 15% lower dementia risk
Starting statins soon after a type 2 diabetes diagnosis may do more than protect the heart. In a nationwide Danish study of more than 132,000 people, those who began statin treatment within a year of diagnosis had a 15% lower…
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Cancer cases could surge 67% worldwide by 2050
Cancer is becoming an even larger global health threat, with nearly 21 million people diagnosed and 9.8 million dying from the disease in 2024. New estimates suggest about 1 in 5 people worldwide will develop cancer during their lifetime, while…
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Scientists find breast cancer cells hiding behind protective “shields”
Researchers have mapped breast tumors in striking detail and uncovered hidden pockets of dormant cancer cells that may help explain why cancer can return after treatment. Unlike rapidly dividing cells, these quiet cells can essentially hibernate, allowing them to evade…
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One immune switch may help drive aging across the body
Aging may be partly fueled by immune cells losing their ability to clear away damaged, inflammation-promoting cells. Blocking a single receptor restored that cleanup process in mice, reducing inflammation and helping their organs, muscles, and memory remain remarkably youthful.
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Each extra hour of prolonged sitting linked to 9% higher cancer death risk
Sitting for long, uninterrupted stretches may carry greater health risks than sitting the same amount of time in shorter bouts. Researchers found that each extra hour of prolonged sedentary behavior was associated with a 9% higher risk of cancer death.…
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High blood sugar may help cancer cells hide from the immune system
Researchers discovered a possible way cancer cells hide from the immune system: they build a thick, sugar-rich coating around themselves. High blood sugar can strengthen this protective shield under conditions that resemble the environment inside tumors, with the protein HSF1…
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Researchers unveil sustainable spirulina solution to vitamin B12 deficiency
Researchers have produced a form of Spirulina containing biologically active vitamin B12 at levels comparable to beef. By carefully controlling the light used to grow the algae, they overcame a major problem with conventional Spirulina, which mainly contains a form…
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A cancer therapy put severe rheumatoid arthritis into remission
CAR T-cell therapy dramatically reduced disease activity in six people with severe rheumatoid arthritis that had resisted other treatments, with three achieving medication-free remission. The treatment may work by clearing out harmful immune cells and effectively rebooting part of the…
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Vitamin C won’t prevent most colds, but it may do one small thing
The belief that huge doses of vitamin C can ward off colds was popularized more than 50 years ago by Nobel Prize winner Linus Pauling. Since then, larger studies have found that vitamin C does not prevent most people from…
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Shingles vaccine linked to 24% lower dementia risk
Older adults who received the Shingrix shingles vaccine were 24% less likely to be diagnosed with dementia over four years in a study of more than 500,000 people. Researchers estimate the difference could amount to roughly one dementia case prevented…
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Supercharged “natural killer” cells could be a powerful new cancer weapon
Researchers have found a way to supercharge natural killer cells, powerful immune cells that can attack cancer, so they can penetrate solid tumors and keep fighting once inside. In mice, these specially prepared tissue-resident cells slowed the growth of several…
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